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Regenerex™

Regenerex™ Porous Titanium Construct combines a clinically proven material with technology that provides optimal pore structure for rapid ingrowth, initial stability, strength and flexibility

RegenerexClinically Proven Material.  Advanced Porous Technology.

Uniting the proven clinical history of titanium with an enhanced interconnecting pore structure, Regenerex™ Porous Titanium Construct is a revolutionary technology engineered for rapid bone ingrowth. Two weeks after implantation in a canine model, Regenerex™ acetabular implants have displayed bony integration and vascularization,1,2 which allows for the formation of blood vessels in the bony tissue.

Titanium Construct with 35 Years of Clinical Use

  • Titanium has been used clinically for more than 35 years3 and is proven to be extremely biocompatible4

Optimum Pore Structure for Rapid Bone Ingrowth

High Porosity

  • Average porosity of 67%1
  • Optimized for vascularized osteogenesis,5 which allows for the formation of bony tissue and blood vessels
  • Consistency of the construct's porosity is achieved by utilizing proprietary manufacturing processes

Optimal Pore Size Range

  • Pore size within the Regenerex™ structure ranges from 100 to 600 microns (one millionth of a meter) with an average pore size of 300 microns1

Initial Stability

  • 16% rougher than competitive porous metal,1 the initial scratch-fit stability and fixation of Regenerex™ implants is well-suited for acetabular reconstruction

Strong, Yet Flexible

  • Regenerex™ construct is 300% stronger than competitive porous metal1 under compressive loads, which comprise the forces most often seen in the acetabulum after total hip arthroplasty6
  • Maintains a strong construct without increasing the stiffness of the implant
  • Maintains a low modulus1 with a structure similar to bone
  • Regenerex™ material is manufactured from the same titanium alloy used in Biomet's clinically proven PPS® Porous Plasma Spray7,8,9

1 Data on file at Biomet. Bench test results are not necessarily indicative of clinical performance.
2 Testing done on animal models.
3 Hahn, H. and Palich,W. Preliminary Evaluation of Porous Metal Surfaced Titanium for Orthopedic Implants. Journal of Biomedical Materials Research. 4(4): 571-77, 1970.
4 Hoffman, A.A. "Response of Human Cancellous Bone to Identically Structured Commercially Pure Titanium and Cobalt Chromium Alloy Porous-Coated Cylinders." Clinical Materials. 14:101-115, 1993.
5 Karageorgiou, V. and Kaplan, D. Porosity of 3-D Biomaterial Scaffolds and Osteogenesis. Biomaterials. 26(27): 5474-91, 2005.
6 Lionberger, D. et al. Effects of Prosthetic Acetabular Replacement on Strains in the Pelvis. Journal of Orthopaedic Research. 3(3): 372-79, 1985.
7 Marshall, A.D. et al. Cementless Titanium Tapered-Wedge Femoral Stem 10- to 15-Year Follow-Up. Journal of Arthroplasty. 19(5): 546-52, 2004.
8 Head, W.C. et al. A Titanium Cementless Calcar Replacement Prosthesis in Revision Surgery of the Femur: 13-year experience. Journal of Arthroplasty. 16(8 Suppl):183-87, 2001.
9 Berend, K.R. et al. The Titanium Taper: The New Gold Standard in Primary Hip Replacement. Minimum 15-year Follow-Up of the Mallory-Head Porous Femoral Component. Poster presented at the 118th Annual Meeting of the American Orthopaedic Association. Huntington Beach, CA. June 2005.