Septocoll® E

Septocoll® E is a resorbable, equine collagen fleece. It has a hemostatic effect and contains gentamicin to give prophylactic local antibiotic protection.

Resorbable collagen for hemostasis

Due to their favorable physical surface properties, collagen fleeces shorten the bleeding time and reduce blood loss. In contact with blood, collagen causes platelet aggregation.

Large numbers of platelets accumulate on the collagen fleece and release coagulation factors. In conjunction with plasma factors these induce fibrinogenesis. They support the overall wound healing process by promoting rapid collagen and protein synthesis.

The collagen used to manufacture Septocoll® E is obtained only from equine tendons. TSE (Transmissible Spongiform Encephalopathy) does not occur in horses.

Biological resorption of Septocoll® E is complete after around four weeks.

Additional surgery to remove the hemostatic material is not necessary.

Scope of application

Septocoll® E is suitable for use in bone and soft-tissue surgery in all disciplines of septic and aseptic surgery. The application of Septocoll® E can be recommended as a hemostat for:

Potentially contaminated wounds
Contaminated wounds
Revision operations in septic surgery

We have optimized the use of Septocoll® E in surgical applications: The fleece does not stick to surgical instruments and can be handled, shaped and cut easily with precision.

Additional antibacterial effect

Septocoll® E is impregnated with gentamicin to give antibiotic protection. It can therefore be applied anywhere, where reliable protection against secondary infection is required.

Septocoll® E is the only fleece on the market that contains two gentamicin salts:

Gentamicin sulfate is highly water-soluble and enables a rapid release of the active substance.
Gentamicin crobefate – recognizable by its distinctive yellow colour – is less water-soluble and thus induces a protracted release of gentamicin.

Fleeces only impregnated with gentamicin sulfate released 90% of their gentamicin sulfate content within 48 hours. Fleeces also impregnated with gentamicin crobefate, however, released gentamicin over a period of 10 days. High initial gentamicin concentrations and lasting local antibiotic protection – create optimum conditions for a rapid, smooth healing process.

Features

Hemostatic, resorbable and well tolerated
Easy Handling
Medical device – highest safety class III
Protracted gentamicin release
TSE-safety due to equine collagen

Literature

(1) Gruessner U. et al. Clinical experience with a new dual component gentamicin collagen fleece (Septocoll®) in the treatment of chronic osteomyelitis of the long tubular bones. Biomaterials in surgery 1998 : 26-35
(2) Gruessner U. et al. Improvement of perineal wound healing by local administration of gentamicin-impregnated collagen fleeces after abdominoperineal excision of rectal cancer. The American Journal of Surgery, (2001) Vol.182, No. 5, 502-509
(3) Gruessner U. et al. Humanpharmakokinetik des neuen Gentamicin-Kollagen-Vlieses Septocoll® bei knochenchirurgischen Eingriffen. Osteosynthese International [Suppl 1] (2000) 8 : 43-48
(4) Holzer B et al. Efficacy and tolerance of a new gentamicin collagen fleece (Septocoll®) after surgical treatment of a pilonidal sinus. Colorectal Disease (2003)5 : 222-227
(5) Moser A. Comparative human pharmacokinetics of two gentamicin-containing collagen carriers. Biomaterials in surgery 1998 : 21-25
(6) Walenkamp G. et al. Pharmacokinetics of two gentamicin collagen fleeces in animal experiments. Biomaterials in surgery 1998 : 18-20